Prostate Cancer Screening in a Cohort of Healthy Population of Eastern Nepal: an Explanatory Trial Study

Prostate cancer (PCa) is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide with an estimated 899,000 new cases and 258,000 new deaths in 2008. Out of this 72% of the cases and 53% of the deaths were found in developed countries representing <20% of the world population. Prostate cancer incidence rates varied 24-fold worldwide in 2008 with the highest estimated rates in Australia/ New Zealand, western Europe, North America, and the Caribbean and the lowest in south central Asia, northern Africa, and eastern Asia (Ferlay et al., 2010). Screening for prostate cancer aims to decrease mortality and morbidity from the disease by increasing the chances of successful treatment through early detection (Rabah and Arafa, 2010). Total PSA is the most useful screening test for the diagnosis of prostate cancer and the addition of DRE improves the detection rate of prostate